Scientific basis for the use of melatonin in COVID 19

Melatonin is a hormone that acts facilitating the appearance of physiological sleep It has also very evident antinflammatory and antioxidant capacities result in beneficial actions on aging processes cardiovascular system lungs where our group detected protective action against oxidative stress , inflammation apoptosis . Although melatonin not viricidal by itself some models viral infections it demonstrated its ability to reduce load oxidation, reducing severity disease. In COVID 19 been shown be able interfere with infectious process takes place through ACE2 EGF receptors being block these interactions thus viremia .It activation NLRP3 inflammasome dramatically massive secretion cytokines markedly hyperinflammation leading better evolution disease .For all reasons could play an important role treatment 19.